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In obesity, an increased number of pro-inflammatory immune response cells are found in adipose tissue. Īdipose tissue has important endocrine functions regulating energy homeostasis, insulin sensitivity, lipid and carbohydrate metabolism. Compared to lifestyle intervention and pharmacological treatment, bariatric surgery leads to greater weight loss and metabolic improvement in patients with severe obesity. Weight loss reduces existing co-morbidities in patients with obesity and may cause remission of T2D. Severe obesity is associated with highly elevated risk of adverse health outcomes including type 2 diabetes (T2D), hypertension, dyslipidaemia, and cardiovascular diseases, as well as premature death and several forms of cancers. The specific roles of these authors are articulated in the author contributions´ section.Ĭompeting interests: Updated Competing Interest statement: The affiliation with Bevital does not alter our adherence to PLOS ONE policies on sharing data and materials. The funders did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funder, Bevital, provided support in the form of salaries for authors, ØM and AU. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: West Norway Regional Health Authority funded costs for the analysis.

Received: JAccepted: JanuPublished: February 5, 2018Ĭopyright: © 2018 Christensen et al. PLoS ONE 13(2):Įditor: Massimo Pietropaolo, Baylor College of Medicine, UNITED STATES (2018) Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery.

Citation: Christensen MHE, Fadnes DJ, Røst TH, Pedersen ER, Andersen JR, Våge V, et al.

Spss download for mac baylor college of medicine